Yoshino M, Yoshino J, Kayser BD, et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science, 372(6547), 1224-1229. doi:10.1126/science.abe9985
RCT (ランダム化比較試験)根拠: 予備的
Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA (2016). Metformin as a tool to target aging. Cell Metabolism, 23(6), 1060-1065. doi:10.1016/j.cmet.2016.05.011
総説根拠: 予備的
Miller RA, Harrison DE, Astle CM, et al. (2014). Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell, 13(3), 468-477. doi:10.1111/acel.12194
動物実験根拠: 中
Kraig E, Linehan LA, Liang H, et al. (2018). A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort. Experimental Gerontology, 105, 53-69. doi:10.1016/j.exger.2017.12.026
RCT (ランダム化比較試験)根拠: 予備的
Kiechl S, Pechlaner R, Willeit P, et al. (2018). Higher spermidine intake is linked to lower mortality: a prospective population-based study. American Journal of Clinical Nutrition, 108(2), 371-380. doi:10.1093/ajcn/nqy102
コホート研究根拠: 低
Andreux PA, Blanco-Bose W, Ryu D, et al. (2019). The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism, 1(6), 595-603. doi:10.1038/s42255-019-0073-4
RCT (ランダム化比較試験)根拠: 予備的